Ep. #612 | GLP Knowledge – Are They Your Best Shot? With Ashley Koff

By Jenn Pike | September 7, 2026

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In this episode, I’m sitting down with Ashley Koff, registered dietitian, USA Today bestselling author of Your Best Shot, and founder of the Better Nutrition Program, for a conversation I’ve wanted to have for a long time. Not another “are GLP-1s good or bad” debate, but a real dive into the science, the nuance, and the questions I don’t think enough of us are asking before starting one of these medications.

In this episode we cover:

  • Why GLP-1 and GIP are “weight health hormones,” not just weight-loss drugs 
  • The receptor-site “garage” analogy that finally made hormone signaling click for me
  • Why muscle loss on these medications is a red flag, not a badge of honor 
  • The digestive-health foundation Ashley says nobody skips without consequences
  • Why HRT and GLP-1s are showing up together in new research, and what that combination might mean for women in perimenopause
  • The real reasons people come off these medications 
  • Why Ashley says walk away from anyone selling a hormone (any hormone) as “the solution”

Let’s dive in!

Thank you for joining us today. If you could rate, review & subscribe, it would mean the world to me! While you’re at it, take a screenshot and tag me @jennpike to share on Instagram – I’ll re-share that baby out to the community & once a month I’ll be doing a draw from those re-shares and send the winner something special!

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Have a question? Send it over to hello@jennpike.com and I’ll do my best to share helpful insights, thoughts and advice.

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